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Image Search Results
Journal: The Journal of Physiology
Article Title: Restoration of metabolic health by decreased consumption of branched‐chain amino acids
doi: 10.1113/JP275075
Figure Lengend Snippet: A, schematic representation of the experimental plan; mice were preconditioned with a WD for 12 weeks and then randomized to the five experimental groups shown, whereas chow‐fed Control mice were placed on an amino acid defined Control diet. B, weight as well as (C) adipose and lean mass, of mice in each experimental group, was tracked (n = 12 mice per group). D, epididymal WAT was collected at necropsy and weighed (n = 11–12 mice per group; * P < 0.05, Dunnett's test following ANOVA, ** P < 0.05, Bonferroni's test). E, 2 and 10 weeks following the start of the specified dietary intervention, food intake was assessed over a 4 day period in home cages, calculated as kcal day g−1 body weight (n = 6–7 cages per group; means with the same lowercase letter are not significantly different from each other, Tukey–Kramer test following ANOVA, P < 0.05). F, spontaneous activity and energy expenditure were measured using metabolic chambers ∼7–8 weeks after the start of the dietary intervention (n = 5–8 mice per group; means with the same lowercase letter are not significantly different from each other, Tukey–Kramer test following ANOVA, P < 0.05). Error bars represent the SE.
Article Snippet: Error bars represent the SE. table ft1 table-wrap mode="anchored" t5 Table 3 caption a7 Amino acid defined diets Control AA WD Control AA WD High BCAA WD Low BCAA WD Low AA Teklad diet number TD.140711 TD.160186 TD.160189 TD.160188 TD.160187 Colour Red Aqua Green Black Orange Formula (g kg −1 ) l ‐Alanine 9.38 9.38 5.5861 11.8183 3.05 l ‐Arginine 6.3 6.3 6.3 6.3 2.05 l ‐Asparagine 20.58 20.58 17.7668 22.388 6.7 l ‐Aspartic acid 20.58 20.58 14.9108 24.2237 6.7 l ‐Cysteine 7.2 7.2 7.2 7.2 2.34 l ‐Glutamic acid 28.97 28.97 22.7053 32.9963 9.43 l ‐Glutamine 33.77 33.77 30.6311 35.7873 11.0 Glycine 2.96 2.96 0.96 5.0141 0.96 l ‐Histidine HCl, monohydrate 4.6 4.6 4.6 4.6 1.5 l ‐Isoleucine 7.8 7.8 15.6 2.54 2.54 l ‐Leucine 25.4 25.4 50.8 8.27 8.27 l ‐Lysine HCl 20.38 20.38 20.38 20.38 6.64 l ‐Methionine 6.7 6.7 6.7 6.7 2.18 l ‐Phenylalanine 6.6 6.6 6.6 6.6 2.15 l ‐Proline 7.41 7.41 2.5094 10.5596 2.41 l ‐Serine 7.41 7.41 2.9359 10.2855 2.41 l ‐Threonine 9.7 9.7 9.7 9.7 3.16 l ‐Tryptophan 3.4 3.4 3.4 3.4 1.1 l ‐Tyrosine 6.9 6.9 6.9 6.9 2.25 l ‐Valine 8.4 8.4 16.8 2.735 2.735 Sucrose 291.248 341.46 341.46 341.46 341.46 Corn starch 150.0 49.63 45.3573 52.6511 132.0625 Maltodextrin 150.0 49.63 45.3573 52.6511 132.0625 Anhydrous milkfat – 210 210 210 210 Cholesterol – 1.5 1.5 1.5 1.5 Corn oil 52.0 – – – – Olive oil 29.0 – – – – Cellulose 30.0 50 50 50 50 Mineral mix, AIN‐93M‐MX (94049) 35.0 35 35 35 35 Calcium phosphate Ca(H PO ) ·H O 8.2 8.2 8.2 8.2 8.2 Vitamin mix, Teklad (40060) 10.0 10.0 10.0 10.0 10.0 TBHQ, anti‐oxidant 0.012 0.04 0.04 0.04 0.04 Food colouring 0.1 0.1 0.1 0.1 0.1 % kcal from: Protein (based on N × 6.25) 22 20.7 21.4 20.2 6.8 Carbohydrates 59.4 38.5 37.8 39.0 52 Fat 18.6 40.9 40.8 40.9 41.2 kcal g −1 3.9 4.6 4.6 4.6 4.6 Open in a
Techniques: Control, Activity Assay
Journal: The Journal of Physiology
Article Title: Restoration of metabolic health by decreased consumption of branched‐chain amino acids
doi: 10.1113/JP275075
Figure Lengend Snippet: Composition of amino acid defined WDs
Article Snippet: Error bars represent the SE. table ft1 table-wrap mode="anchored" t5 Table 3 caption a7 Amino acid defined diets Control AA WD Control AA WD High BCAA WD Low BCAA WD Low AA Teklad diet number TD.140711 TD.160186 TD.160189 TD.160188 TD.160187 Colour Red Aqua Green Black Orange Formula (g kg −1 ) l ‐Alanine 9.38 9.38 5.5861 11.8183 3.05 l ‐Arginine 6.3 6.3 6.3 6.3 2.05 l ‐Asparagine 20.58 20.58 17.7668 22.388 6.7 l ‐Aspartic acid 20.58 20.58 14.9108 24.2237 6.7 l ‐Cysteine 7.2 7.2 7.2 7.2 2.34 l ‐Glutamic acid 28.97 28.97 22.7053 32.9963 9.43 l ‐Glutamine 33.77 33.77 30.6311 35.7873 11.0 Glycine 2.96 2.96 0.96 5.0141 0.96 l ‐Histidine HCl, monohydrate 4.6 4.6 4.6 4.6 1.5 l ‐Isoleucine 7.8 7.8 15.6 2.54 2.54 l ‐Leucine 25.4 25.4 50.8 8.27 8.27 l ‐Lysine HCl 20.38 20.38 20.38 20.38 6.64 l ‐Methionine 6.7 6.7 6.7 6.7 2.18 l ‐Phenylalanine 6.6 6.6 6.6 6.6 2.15 l ‐Proline 7.41 7.41 2.5094 10.5596 2.41 l ‐Serine 7.41 7.41 2.9359 10.2855 2.41 l ‐Threonine 9.7 9.7 9.7 9.7 3.16 l ‐Tryptophan 3.4 3.4 3.4 3.4 1.1 l ‐Tyrosine 6.9 6.9 6.9 6.9 2.25 l ‐Valine 8.4 8.4 16.8 2.735 2.735 Sucrose 291.248 341.46 341.46 341.46 341.46 Corn starch 150.0 49.63 45.3573 52.6511 132.0625 Maltodextrin 150.0 49.63 45.3573 52.6511 132.0625 Anhydrous milkfat – 210 210 210 210 Cholesterol – 1.5 1.5 1.5 1.5 Corn oil 52.0 – – – – Olive oil 29.0 – – – – Cellulose 30.0 50 50 50 50 Mineral mix, AIN‐93M‐MX (94049) 35.0 35 35 35 35 Calcium phosphate Ca(H PO ) ·H O 8.2 8.2 8.2 8.2 8.2 Vitamin mix, Teklad (40060) 10.0 10.0 10.0 10.0 10.0 TBHQ, anti‐oxidant 0.012 0.04 0.04 0.04 0.04 Food colouring 0.1 0.1 0.1 0.1 0.1 % kcal from: Protein (based on N × 6.25) 22 20.7 21.4 20.2 6.8 Carbohydrates 59.4 38.5 37.8 39.0 52 Fat 18.6 40.9 40.8 40.9 41.2 kcal g −1 3.9 4.6 4.6 4.6 4.6 Open in a
Techniques: Control
Journal: The Journal of Physiology
Article Title: Restoration of metabolic health by decreased consumption of branched‐chain amino acids
doi: 10.1113/JP275075
Figure Lengend Snippet: A, schematic representation of experimental plan; mice were preconditioned with a WD for 12 weeks and then randomized to the four experimental groups shown, whereas chow‐fed Control mice were placed on an amino acid defined Control diet. B, weight, as well as (C) adipose and lean mass of mice in each experimental group was tracked (n = 12 mice per group). D, food intake was measured 2 weeks after special diet feeding began (n = 8 cages per group; means with the same lowercase letter are not significantly different from each other, Tukey–Kramer test following ANOVA, P < 0.05). E, body composition at diet intervention start and 12 weeks later. Error bars represent the SE.
Article Snippet: Error bars represent the SE. table ft1 table-wrap mode="anchored" t5 Table 3 caption a7 Amino acid defined diets Control AA WD Control AA WD High BCAA WD Low BCAA WD Low AA Teklad diet number TD.140711 TD.160186 TD.160189 TD.160188 TD.160187 Colour Red Aqua Green Black Orange Formula (g kg −1 ) l ‐Alanine 9.38 9.38 5.5861 11.8183 3.05 l ‐Arginine 6.3 6.3 6.3 6.3 2.05 l ‐Asparagine 20.58 20.58 17.7668 22.388 6.7 l ‐Aspartic acid 20.58 20.58 14.9108 24.2237 6.7 l ‐Cysteine 7.2 7.2 7.2 7.2 2.34 l ‐Glutamic acid 28.97 28.97 22.7053 32.9963 9.43 l ‐Glutamine 33.77 33.77 30.6311 35.7873 11.0 Glycine 2.96 2.96 0.96 5.0141 0.96 l ‐Histidine HCl, monohydrate 4.6 4.6 4.6 4.6 1.5 l ‐Isoleucine 7.8 7.8 15.6 2.54 2.54 l ‐Leucine 25.4 25.4 50.8 8.27 8.27 l ‐Lysine HCl 20.38 20.38 20.38 20.38 6.64 l ‐Methionine 6.7 6.7 6.7 6.7 2.18 l ‐Phenylalanine 6.6 6.6 6.6 6.6 2.15 l ‐Proline 7.41 7.41 2.5094 10.5596 2.41 l ‐Serine 7.41 7.41 2.9359 10.2855 2.41 l ‐Threonine 9.7 9.7 9.7 9.7 3.16 l ‐Tryptophan 3.4 3.4 3.4 3.4 1.1 l ‐Tyrosine 6.9 6.9 6.9 6.9 2.25 l ‐Valine 8.4 8.4 16.8 2.735 2.735 Sucrose 291.248 341.46 341.46 341.46 341.46 Corn starch 150.0 49.63 45.3573 52.6511 132.0625 Maltodextrin 150.0 49.63 45.3573 52.6511 132.0625 Anhydrous milkfat – 210 210 210 210 Cholesterol – 1.5 1.5 1.5 1.5 Corn oil 52.0 – – – – Olive oil 29.0 – – – – Cellulose 30.0 50 50 50 50 Mineral mix, AIN‐93M‐MX (94049) 35.0 35 35 35 35 Calcium phosphate Ca(H PO ) ·H O 8.2 8.2 8.2 8.2 8.2 Vitamin mix, Teklad (40060) 10.0 10.0 10.0 10.0 10.0 TBHQ, anti‐oxidant 0.012 0.04 0.04 0.04 0.04 Food colouring 0.1 0.1 0.1 0.1 0.1 % kcal from: Protein (based on N × 6.25) 22 20.7 21.4 20.2 6.8 Carbohydrates 59.4 38.5 37.8 39.0 52 Fat 18.6 40.9 40.8 40.9 41.2 kcal g −1 3.9 4.6 4.6 4.6 4.6 Open in a
Techniques: Control